![]() ![]() ![]() Immunization-driven decrease in chlamydial load was associated with increases in IFNg, IgA, IgG1, and IgG2a. Depending on chlamydial species, single and multiple recombinant protein, viral and bacterial vectors, dendritic transfer, and dead whole pathogen were most effective at reducing chlamydial load. Results: Chlamydial immunization studies most often used (78%) laboratory mouse models. Methods: We systematically extracted data from studies that included chlamydial load or host immune parameter measurements, estimating 4,453 standardized effect sizes between control and chlamydial immunization experimental groups. Exemplary of this problem is vaccine development against Chlamydia, a pathogen of global public health and financial importance. Background: Vaccine-development research is proliferating making it difficult to determine the most promising vaccine candidates. ![]()
0 Comments
Leave a Reply. |